Immunogenomic profile at baseline predicts host susceptibility to clinical malaria

Introduction Host gene and protein expression impact susceptibility to clinical malaria, but the balance of immune cell populations, cytokines genes that contributes protection, remains incompletely understood. Little is known about determinants host malaria at a time when acquired immunity developing. Methods We analyzed peripheral blood mononuclear cells (PBMCs) collected from children who differed in all small town Mali. PBMCs were aged 4-6 years start, peak end season. characterized composition cytokine secretion for subset 20 per timepoint (10 with no symptomatic age-matched 10 >2 malarial illnesses), patterns six (three cohort) timepoint. Results observed differences between two groups related death inflammation; particular, inflammatory such as CXCL10 STAT1 apoptotic XAF1 upregulated susceptible before transmission season began. also noted higher frequency HLA-DR+ CD4 T protected during comparable levels after stimulation schizonts across three points. Conclusion This study highlights importance baseline signatures determining disease outcome. Our data suggests can serve predictive markers malaria.